I've always assumed that there is some configuration needed on my part via my.cnf for MySQL depending on your use, hence the default my.large.cnf etc.. templates. Would this type of service assume that Amazon is doing something to optimize the configurations of the MySQL server based on it's use patterns? Or do the my.cnf settings not matter if they are set appropriately for the instance size - regardless of the use type? i.e. would there really be one setting for a server with 1,000's of tinny queries versus a server with 10's of huge queries?